Analysis of Carcinogenic Tobacco- Specific Nitrosamines in Mainstream Cigarette Smoke Using an Agilent J&W DB-35ms Ultra Inert GC Column
ثبت نشده
چکیده
A simple and sensitive method for routine analysis of TSNAs in mainstream cigarette smoke has been developed. Cigarette smoke particulate matter was collected according to ISO 4387. The particulate matter was extracted with methylene chloride, cleaned up with an Agilent Bond Elut Alumina B SPE cartridge, and analyzed using an Agilent 7000A Triple Quadrupole GC/MS system with an Agilent J&W DB-35ms Ultra Inert GC column. The resulting low method detection limit, good linearity, and sample recovery were demonstrated, as was observed for NNK in this study.
منابع مشابه
Organophosphorus Pesticides Analysis Using an Agilent J&W DB-5ms Ultra Inert Capillary GC Column
Agilent Technologies Inc. has implemented new testing procedures to more effectively evaluate GC column inertness performance. This new testing procedure employs deliberately aggressive probes to thoroughly investigate and verify column inertness and quality. In challenging separations, knowing that the GC column has been thoroughly investigated for column inertness gives analysts higher confid...
متن کاملAn analysis of the role of tobacco-specific nitrosamines in the carcinogenicity of tobacco smoke.
Cigarette smoke is a complex mixture consisting of more than 4500 chemicals, including several tobacco-specific nitrosamines (TSNA). TSNA typically form in tobacco during the post-harvest period, with some fraction being transferred into mainstream smoke when a cigarette is burned during use. The most studied of the TSNA is 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). NNK has been show...
متن کاملDetermination of Tobacco Specific Nitrosamines in Cigarette Mainstream Smoke – Gc-tea Method
Between 1999 and 2005, a Task Force composed of CORESTA members has studied the existing methodologies for the determination of the Tobacco Specific Nitrosamines (TSNAs) in the mainstream smoke of cigarettes. Several methods have been proposed for this determination, which are mainly based on two types of analytical methodologies: GC-TEA (Gas Chromatography with a Thermal Energy Analyser as det...
متن کاملAnalysis of Organic Acids and Alcohols Using the Agilent J&W DB-624UI Ultra Inert GC Column Authors
A 26-component mix of aliphatic short chain and aromatic alcohols and carboxylic acids was used to evaluate the recently introduced Agilent J&W DB-624UI column to show acceptable peak shape and resolution. The column was compared to non-Agilent 624 phases. Organic acids had reasonable peak width and peak symmetry for a narrow range of volatilities (C3 through C8) on the DB-624UI column, suggest...
متن کاملAssessment of tobacco-specific nitrosamines in the tobacco and mainstream smoke of Bidi cigarettes.
Bidi cigarettes, or bidis, are a tobacco product that originated in India and have been gaining popularity in the USA during the past few years, particularly with adolescents. As with conventional cigarettes, tobacco and smoke from bidis contain chemical constituents including carcinogenic chemicals such as the tobacco-specific nitrosamines (TSNAs). To help better assess the potential public he...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011